- 695 deaths. March 18, 1925, in Missouri, Illinois and Indiana.
- 216 deaths. April 5, 1936, in Tupelo, Mississippi.
- 203 deaths. April 6, 1936, in Gainesville, Georgia.
- 181 deaths. April 9, 1947, in Woodward, Oklahoma.
- 158 deaths. May 22, 2011, in Joplin, Missouri.
- 143 deaths. April 24, 1908, in Amite, Louisiana, and Purvis, Mississippi.
- 116 deaths. June 8, 1953, in Flint, Michigan.
- 114 deaths. May 11, 1953 in Waco, Texas.
- 114 deaths. May 18, 1902 in Goliad, Texas.
- 103 deaths. March 23, 1913, in Omaha, Nebraska.
Source: National Oceanic and Atmospheric Administration.